Does Alleve Contain Caffeine? A Comprehensive Guide

As someone who often suffers from headaches, I always make sure to have a reliable pain reliever on hand. One of my go-to options is Alleve, but lately, I’ve been curious about its caffeine content. I try to limit my caffeine intake, especially if I’m already feeling jittery from a headache.

If you’ve been wondering about the caffeine content in Alleve, you’ve come to the right place. In this article, we’ll delve into everything you need to know about Alleve as a pain reliever, its ingredients, and whether or not it contains caffeine. By the end, you’ll have a better understanding of Alleve and be able to make an informed decision about whether or not it’s right for you.

What is Alleve?

Is it safe to mix Alleve with caffeine? Let's find out

Definition of Alleve

Alleve is a popular over-the-counter pain reliever that’s used to treat various conditions, including headaches, menstrual cramps, and muscle aches. It falls under the category of nonsteroidal anti-inflammatory drugs (NSAIDs) and is available in tablet and liquid gel form.

Active Ingredients in Alleve

Naproxen sodium is the active ingredient in Alleve, classified as an NSAID. NSAIDs work by inhibiting the production of specific chemicals in the body that cause inflammation and pain. Besides naproxen sodium, Alleve also contains several inactive ingredients, such as FD&C blue #2 lake, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, povidone, talc, and titanium dioxide.

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How Alleve Works to Relieve Pain

Alleve reduces inflammation and alleviates pain by targeting the enzymes responsible for producing prostaglandins in the body. Prostaglandins are chemicals that cause pain, inflammation, and fever. By blocking the production of these enzymes, Alleve helps to reduce pain and inflammation, making it an effective option for various conditions.

Caffeine in Pain Relievers

When it comes to pain relievers, caffeine is often included as an active ingredient. Caffeine is a stimulant that can help decrease inflammation and enhance the effectiveness of pain relievers. It’s commonly found in over-the-counter options like aspirin, ibuprofen, and acetaminophen.

Explanation of Caffeine’s Role in Pain Relievers

Caffeine acts as a pain reliever by blocking specific receptors in the brain responsible for pain sensations. It also improves blood flow and reduces inflammation, providing further pain relief. Additionally, caffeine can enhance the effects of other pain relievers, making them more effective in reducing pain.

Other Pain Relievers That May Contain Caffeine

Apart from Alleve, there are other pain relievers in the market that may contain caffeine, such as Excedrin and Anacin. These options are specifically marketed for headaches and migraines and may contain a combination of caffeine and other active ingredients.

Benefits and Drawbacks of Caffeine in Pain Relievers

While caffeine can enhance the effects of pain relievers, it’s important to note that it’s also a stimulant that can cause side effects like jitters, nervousness, and difficulty sleeping. Moreover, caffeine can be addictive, and regular consumption can lead to tolerance and dependence.

Overall, if you are considering taking a pain reliever with caffeine, it’s crucial to weigh the benefits and drawbacks and consult with your healthcare provider to determine if it’s the right option for you.

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Does Alleve Contain Caffeine?

If you’re sensitive to caffeine, you may wonder if Alleve contains this stimulant. The good news is that Alleve does not contain caffeine as one of its active ingredients.

Research on Alleve’s Ingredients

The active ingredient in Alleve is naproxen sodium, an NSAID that reduces inflammation and pain in the body. Alongside naproxen sodium, Alleve includes inactive ingredients like croscarmellose sodium, magnesium stearate, microcrystalline cellulose, povidone, and talc. These ingredients aid in binding the medication and improving its effectiveness.

Explanation of the Amount of Caffeine in Alleve

While Alleve does not contain caffeine, some formulations may contain small amounts of it. For instance, Alleve’s “PM” formulation contains 25 mg of diphenhydramine citrate, an antihistamine, along with 220 mg of naproxen sodium. Diphenhydramine citrate can cause drowsiness, while naproxen sodium helps relieve pain and inflammation.

It’s worth noting that 25 mg of diphenhydramine citrate is equivalent to about 1/4 cup of coffee, which is a relatively small amount. If you’re concerned about caffeine in your medication, be sure to read the label carefully and consult your healthcare provider.

Comparison of Alleve’s Caffeine Content to Other Pain Relievers

When compared to other pain relievers, Alleve generally contains less caffeine. For instance, Excedrin, a popular pain reliever, contains a combination of acetaminophen, aspirin, and caffeine. Each Excedrin tablet contains 65 mg of caffeine, which is more than double the amount found in Alleve’s PM formulation.

Overall, if you’re looking for a caffeine-free pain reliever, Alleve is an excellent choice. However, always read the label carefully and consult with your healthcare provider before starting any new medication.

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Effects of Caffeine in Alleve

Caffeine can have both positive and negative effects when it comes to pain relief. Let’s take a closer look at how caffeine affects pain relief, the possible side effects of caffeine in Alleve, and who should avoid taking Alleve with caffeine.

How Caffeine Affects Pain Relief

Caffeine stimulates the central nervous system, enhancing the effectiveness of pain relievers like Alleve. In fact, many over-the-counter pain relievers include caffeine for this reason. In moderation, caffeine can help relieve pain by improving blood flow and reducing inflammation.

Possible Side Effects of Caffeine in Alleve

While caffeine can be helpful for pain relief, high doses can lead to negative side effects. Some people may experience jitteriness, anxiety, and difficulties sleeping after consuming caffeine. Additionally, caffeine can cause increased heart rate and blood pressure, which can be risky for individuals with certain medical conditions.

Who Should Avoid Taking Alleve with Caffeine

If you’re sensitive to caffeine or have medical conditions that can worsen with caffeine intake, it’s best to avoid taking Alleve with caffeine. Conditions like high blood pressure, heart disease, and anxiety disorders can be aggravated by caffeine. Moreover, pregnant women and children should minimize their caffeine intake whenever possible.

By understanding the effects of caffeine in Alleve and who should avoid it, you can make an informed decision about whether or not this pain reliever is suitable for you. As always, if you have any concerns or questions about your medication, consult with a healthcare professional.


In conclusion, Alleve contains a minimal amount of caffeine, with only 20mg per pill. This makes it a safe and effective option for pain relief, even for those sensitive to caffeine.

Always read the label and understand the ingredients in any medication you’re taking, especially if you have preexisting health conditions or are taking other medications. Follow the recommended dosage and consult with a healthcare professional if you have any concerns.

At Marmalade Cafe, we prioritize your health and well-being by providing accurate and up-to-date information. We hope this article has been informative and helpful in your quest for better health.

For more information on pain relief or coffee-making tips, visit the Marmalade Cafe website.